一、中心介绍

智能医疗器械研究中心Center for Intelligent Medical Equipment and Devices （iMED）（以下简称“iMED中心”）是澳门二十四小时官网设立的首个前沿传感与器械研究中心。中心以临床医学的紧迫需求与前沿发展方向为导向，通过研发具有原创性的新型医疗器械装备，致力于建设创新型的“产·学·研·管·医”的联合开发平台，塑造“创新、想象、创造、执行”的科研文化，以培养具备国际视野和前沿交叉能力的开拓型的创新创业领军人才。

自成立以来，iMED中心引进了4位国家级领军人才与10余位拥有海外学术背景的优秀青年科学家，组建了一支在前沿传感与器械方向具有世界领先水平的科研团队。目前，超过100名研究生在中心从事前沿科学研究，其中包括30余名博士研究生。中心的主要研究方向包括医疗可穿戴与智能器械、植介入器械与手术智能、和生物芯片与组织工程，并建立了医疗器械标准化、医疗器械先进制造与医用核心材料研发等三大开放性科研支撑平台。同期，iMED中心承担了包括国家重点研发计划、中国科学院战略性先导科技专项和基金委面上项目在内的二十余项国家级重点科研项目，并在包括Nature、Nature Nanotechnology、Nature Communications、Advanced Materials、Advanced Functional Materials、Matter、Small在内的顶尖学术期刊上发表了学术论文100余篇。

二、科研进展

1.触觉智能-水下感知能力的仿生皮肤

Chang, Y., Pan, T., et al., Aquatic Skin Enabled by Multi-Modality Iontronic Sensing. Adv. Funct. Mater. 2022, 2205947.

2.触觉智能-透明感知能力的仿生皮肤

Chang, Y., Pan, T., et al., Ultrahigh-transparency and pressure-sensitive iontronic device for tactile intelligence. npj Flex. Electron., 2022,

3.机器人生物学家

Anal. Chem. 2021, 93, 11424

4.微流控智能-单分子检测的纳米液相芯片平台和流式病毒仪

Ye, H., et al, Digital plasmonic nanobubble detection for rapid and ultrasensitive virus diagnostics. Nat. Commun. 2022, 13, 1

5.通过嵌入式打印中空血管

6.通过牺牲模板法制造仿生微腔卵巢

7.复合界面气动打印

8.基于人工智能的皮肤癌智能诊断

9.激光集成纳米工程

Liang Yang, et al, Laser Printed Microelectronics. Nat. Commun. 2023, 14

三、代表性论文

1. Sen Li, Jiantao Huang, Meilan Wang, Ka Deng, Chenhui Guo, Bin Li, Yu Cheng, Hongyan Sun, Hong Ye, Tingrui Pan* and Yu Chang*, Structural Electronic Skin for Conformal Tactile Sensing, Adv. Sci. 2023, 2304106.

2. Yu Cheng, Chenhui Guo, Sen Li, Ka Deng, Jie Tang, Qian Luo, Shiwu Zhang, Yu Chang*and Tingrui Pan*, Aquatic Skin Enabled by Multi-Modality Iontronic Sensing, Adv. Funct. Mater. 2022, 2205947.

3.Jie Tang, Chao Zhao, Qian Luo, Yu Chang*, Zhenguo Yang* and Tingrui Pan*, Ultrahigh-transparency and pressure-sensitive iontronic device for tactile intelligence, npj Flexible Electronics, 2022, 6:54.

4. Yu Chang, Liu Wang, Ruya Li, Zhichao Zhang, Qi Wang, Junlong Yang, Chuan Fei Guo*and Tingrui Pan*, First Decade of Interfacial Iontronic Sensing: From Droplet Sensors to Artificial Skins, Adv. Mater. 2020, 2003464.

5.Baoqing Nie, Siyuan Xing, James D. Brandt and Tingrui Pan*, Droplet-based interfacial capacitive sensing, Lab Chip, 2012, 12, 1110.

6.Zijie Zhu, Ruya Li, and Tingrui Pan*, Imperceptible Epidermal–Iontronic Interface for Wearable Sensing, Adv. Mater. 2018, 1705122.

7.Sen Li, Ning Pan, Zijie Zhu, Ruya Li, Baoqing Li, Jiaru Chu, Guanglin Li, Yu Chang* and Tingrui Pan*, All-in-One Iontronic Sensing Paper, Adv. Funct. Mater. 2019, 1807343.

8. Ruya Li, Yang Si, Zijie Zhu, Yaojun Guo, Yingjie Zhang, Ning Pan, Gang Sun and Tingrui Pan*，Supercapacitive Iontronic Nanofabric Sensing，Adv. Mater. 2017, 1700253.

9. Baoqing Nie, Ruya Li, Jennifer Cao, James D. Brandt, and Tingrui Pan*, Flexible Transparent Iontronic Film for Interfacial Capacitive Pressure Sensing, Adv. Mater. 2015, 27, 6055–6062.

10.Baoqing Nie, Ruya Li, James D. Brandtb and Tingrui Pan*, Iontronic microdroplet array for flexible ultrasensitive tactile sensing, Lab Chip, 2014, 14, 1107–1116.

11.Liu, J., Liu, H., Ye, Y., Fu, H., Chen, K., Lu, Y., Mao, J., Xu, R. X. *,& Sun, M.*, Edge-guided Contrastive Adaptation Network for Arteriovenous Nicking Classification Using Synthetic Data[J]. IEEE Transactions on Medical Imaging.

12.Liu, L., Liu, J., Ye, Y., Liu, H., Chen, K., Li, D., ... & Sun, M.*, Ultra-short-term wind power forecasting based on deep Bayesian model with uncertainty. Renewable Energy, 2023,205, 598-607.

13.Ye, Y., Sun, W. W., Xu, R. X., Selmic, L. E. *, & Sun, M. * , Intraoperative assessment of canine soft tissue sarcoma by deep learning enhanced optical coherence tomography. Veterinary and Comparative Oncology, 2021,19(4), 624-631.

14.Dou, P., Zhang, Y., Zheng, R., Ye, Y., Mao, J., Liu, L., Wu, M.*, & Sun, M.*,Retinal imaging and analysis using machine learning with information fusion of the functional and structural features based on a dual-modal fundus camera. Journal of Mechanics in Medicine and Biology, 2021, 2150030.

15.Zhang, S., Li, B., Liu, L., Hu, Q., Liu, H., Zheng, R., Zhu, Y., Liu, T., Sun, M.*, & Liu, C.* , Prediction of vertical profile of NO₂ using deep multimodal fusion network based on the ground-based 3-D remote sensing. IEEE Transactions on Geoscience and Remote Sensing, 2021

16. Zheng, R., Zhang, S., Liu, L., Luo, Y., & Sun, M.*,Uncertainty in Bayesian deep label distribution learning. Applied Soft Computing, 2021,101, 107046.

17.Qu, Y., Smith, Z. J., Tyler, K., Chang, S., Shen, S., Sun, M. *, & Xu, R. X. * , Applying limiting entropy to quantify the alignment of collagen fibers by polarized light imaging. Mathematical Biosciences and Engineering, 2021,18 (3), 2331-2356.

18.Zheng, Z., Xing, J., Shi, H., Wu, M., Yang, R., Yao, P., & Xu, R. X*,2D scanning SERS probe for early biofilm boundary determination. Sensors and Actuators B: Chemical, 2022,363, 131822.

19.Wu, B., Zhang, F., Xu, L., Shen, S., Shao, P., Sun, M., ... & Xu, R. X*, Modality preserving U-Net for segmentation of multimodal medical images. Quantitative Imaging in Medicine and Surgery, 2023, 13(8), 5242.

20.Zhang, F., Contreras, C. M., Shao, P., Zhao, L., Wu, B., Li, C., & Xu, R. X*., Co-axial projective imaging for augmented reality telementoring in skin cancer surgery. Annals of Biomedical Engineering, 2022,50(12), 1846-1856.

21. Liu, P., Li, C., Xiao, C., Zhang, Z., Ma, J., Gao, J., ... & Xu, R.X.*,  A wearable augmented reality navigation system for surgical telementoring based on Microsoft HoloLens. Annals of biomedical engineering, 2021, 49, 287-298.

22.Liang Yang*, Hongrong Hu, Alexander Scholz, Florian Feist, Gabriel Cadilha Marques, Steven Kraus, Niklas Maximilian Bojanowski, Eva Blasco, Christopher Barner-Kowollik, Jasmin Aghassi-Hagmann, Martin Wegener *, “Laser Printed Microelectronics”, Nature Communications, 2023, 14, 1103. (IF:17.69)

23.Liang Yang, Aso Rahimzadegan, Vincent Hahn, Eva Blasco, Carsten Rockstuhl, and Martin Wegener*, “In-situ diagnostics and role of light-induced forces in metal laser nanoprinting”, Laser & Photonics Reviews, 2022, 2100411.

24.Liang Yang, Frederik Mayer, Uwe H. F. Bunz, Eva Blasco and Martin Wegener*, “Multi-material multi-photon 3D laser micro- and nanoprinting”, Light: Advanced Manufacturing, 2021, 2:17.

25.Liang Yang*, Alexander Münchinger, Muamer Kadic, Vincent Hahn, Frederik Mayer, Eva Blasco, Christopher Barner-Kowollik, and Martin Wegener, “On the Schwarzschild Effect in 3D Two-Photon Laser Lithography”, Advanced Optical Materials, 2019, 7(22):1091040.

26.Liang Yang, Xiaoxiao Chen, Li Wang, Zhijiang Hu, Chen Xin, Marc Hippler, Wulin Zhu, Yanlei Hu,* Jiawen Li, Yucai Wang, Li Zhang, Dong Wu,* and Jiaru Chu,“Targeted Single-Cell Therapeutics with Magnetic Tubular Micromotor by One-Step Exposure of Structured Femtosecond Optical Vortices”, Advanced Functional Materials, 2019, 29(45):1905745.

四、主要研究人员

五、联系方式

中心长期诚聘具有国际视野、创新能力和团队精神的高层次生物医学工程研究人才。研究领域主要包括但不局限于微流控、医疗器械、柔性电子、生物力学、生物医学材料、微纳加工、生物医学光学、人工智能、先进给药等，特别欢迎具有生化实验基础、细胞和动物实验经验或者临床医学背景的申请者。

联系人：何老师 

邮箱：iMED@ustc.edu.cn

座机：0512-62881386

地址：苏州工业园区仁爱路166号明德楼